Ixazomib Synthetic Routes

CAT#: 205857 | Name: Ixazomib | CAS#

Description:

Ixazomib, also known as MLN-2238, is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is also .the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only MLN2238 alleviated osteolytic bone disease in the DP54-Luc model.

Synthetic Routes

Ixazomib - Synthetic Route 1

Synthetic Description

Reference: Lee, Kwang Chung; Lin, Chien Hung; Lin, Shu Chuan; Lin, Hua Hsuan. Process for preparing intermediate compound of ixazomib citrate, and ixazomib citrate made thereby. TW I599571. (Assignee Chunghwa Chemical Synthesis & Biotech Co., Ltd., Taiwan)

Synthetic Reference

Lee, Kwang Chung; Lin, Chien Hung; Lin, Shu Chuan; Lin, Hua Hsuan. Process for preparing intermediate compound of ixazomib citrate, and ixazomib citrate made thereby. TW I599571. (Assignee Chunghwa Chemical Synthesis & Biotech Co., Ltd., Taiwan)

Ixazomib - Synthetic Route 2

Synthetic Description

Reference: Bakale, Roger P.; Mallamo, John P.; Roemmele, Renee Caroline. Proteasome inhibitors and processes for their preparation, purification and use. WO 2012177835. (Assignee Cephalon, Inc., USA)

Synthetic Reference

Bakale, Roger P.; Mallamo, John P.; Roemmele, Renee Caroline. Proteasome inhibitors and processes for their preparation, purification and use. WO 2012177835. (Assignee Cephalon, Inc., USA)

Ixazomib - Synthetic Route 3

Synthetic Description

Reference: Lei, Meng; Zhu, Yongqiang; Feng, Huayun; Wang, Cheng. A dipeptide boronic acids composed of carboxylic acids and α-amino acids, its ester compounds, preparation method thereof and application in treating solid tumor and blood tumor. CN 105732683. (Assignee Nanjing Forestry University, Peop. Rep. China)

Synthetic Reference

Lei, Meng; Zhu, Yongqiang; Feng, Huayun; Wang, Cheng. A dipeptide boronic acids composed of carboxylic acids and α-amino acids, its ester compounds, preparation method thereof and application in treating solid tumor and blood tumor. CN 105732683. (Assignee Nanjing Forestry University, Peop. Rep. China)

Ixazomib - Synthetic Route 4

Synthetic Description

Reference: Li, Dequn. Preparation process of boron-containing compound. CN 106518902. (Assignee Chengdu Beisi Kairui Biotechnology Co., Ltd., Peop. Rep. China)

Synthetic Reference

Li, Dequn. Preparation process of boron-containing compound. CN 106518902. (Assignee Chengdu Beisi Kairui Biotechnology Co., Ltd., Peop. Rep. China)

Ixazomib - Synthetic Route 5

Synthetic Description

Reference: Li, Runtao; Ge, Zemei; Cheng, Qing; Han, Liqiang; Wang, Xin; Cheng, Tieming. Synthesis method of proteasome inhibitor MLN9708. CN 106608883. (Assignee Peking University, Peop. Rep. China)

Synthetic Reference

Li, Runtao; Ge, Zemei; Cheng, Qing; Han, Liqiang; Wang, Xin; Cheng, Tieming. Synthesis method of proteasome inhibitor MLN9708. CN 106608883. (Assignee Peking University, Peop. Rep. China)

Ixazomib - Synthetic Route 6

Synthetic Description

Reference: Zhu, Yongqiang; Lei, Meng; Bai, Enhe; Feng, Huayun. Preparation of deuterated dipeptide boronic acids as proteosome inhibitors. CN 106916177. (Assignee Nanjing Normal University, Peop. Rep. China)

Synthetic Reference

Zhu, Yongqiang; Lei, Meng; Bai, Enhe; Feng, Huayun. Preparation of deuterated dipeptide boronic acids as proteosome inhibitors. CN 106916177. (Assignee Nanjing Normal University, Peop. Rep. China)

Ixazomib - Synthetic Route 7

Synthetic Description

Reference: Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Reddy, Ghojala Venkat; Reddy, Mallepally Venkat. Process for the preparation of ixazomib citrate. IN 201641044033. (Assignee MSN Laboratories Private Limited, R & D Center, India)

Synthetic Reference

Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Reddy, Ghojala Venkat; Reddy, Mallepally Venkat. Process for the preparation of ixazomib citrate. IN 201641044033. (Assignee MSN Laboratories Private Limited, R & D Center, India)

Ixazomib - Synthetic Route 8

Synthetic Description

Reference: Pandey, Maneesh Kumar; Shukla, Sonu Prasad; Tiwari, Raj Narayan; Sokhi, Sarbjot Singh; Singh, Govind; Lahiri, Saswata; Cabri, Walter. A process for the preparation of ixazomib citrate. WO 2018158697. (Assignee Fresenius Kabi Oncology Limited, India)

Synthetic Reference

Pandey, Maneesh Kumar; Shukla, Sonu Prasad; Tiwari, Raj Narayan; Sokhi, Sarbjot Singh; Singh, Govind; Lahiri, Saswata; Cabri, Walter. A process for the preparation of ixazomib citrate. WO 2018158697. (Assignee Fresenius Kabi Oncology Limited, India)

Ixazomib - Synthetic Route 9

Synthetic Description

Reference: Zhu, Yongqiang; Lei, Meng; Bai, Enhe; Feng, Huayun. Preparation of deuterated dipeptide boronic acids as proteosome inhibitors. WO 2018171816. (Assignee Nanjing Lingrui Pharmaceutical Technology Co., Ltd., Peop. Rep. China)

Synthetic Reference

Zhu, Yongqiang; Lei, Meng; Bai, Enhe; Feng, Huayun. Preparation of deuterated dipeptide boronic acids as proteosome inhibitors. WO 2018171816. (Assignee Nanjing Lingrui Pharmaceutical Technology Co., Ltd., Peop. Rep. China)

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