Lenvatinib synthetic routes

CAT#: 100959 | Name: Lenvatinib | CAS#

Purchases for research

Description:

Lenvatinib, also known as E7080, is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.

Synthetic Routes

Lenvatinib - Synthetic Route 1

Lenvatinib - Synthetic Route 1

Synthetic Description

Reference: Naito, Toshihiko; Yoshizawa, Kazuhiro. Preparation of urea moiety-containing quinolinecarboxamide derivatives. WO 2005044788. (Assignee Eisai Co., Ltd., Japan)

Synthetic Reference

Naito, Toshihiko; Yoshizawa, Kazuhiro. Preparation of urea moiety-containing quinolinecarboxamide derivatives. WO 2005044788. (Assignee Eisai Co., Ltd., Japan)

Lenvatinib - Synthetic Route 2

Lenvatinib - Synthetic Route 2

Synthetic Description

Reference: Oruganti, Srinivas; Kandagatla, Bhaskar. Improved process for the preparation of lenvatinib using dimethylformamide as a solvent. IN 201641011188. (Assignee Dr. Reddy's Laboratories Limited, India)

Synthetic Reference

Oruganti, Srinivas; Kandagatla, Bhaskar. Improved process for the preparation of lenvatinib using dimethylformamide as a solvent. IN 201641011188. (Assignee Dr. Reddy's Laboratories Limited, India)

Lenvatinib - Synthetic Route 3

Lenvatinib - Synthetic Route 3

Synthetic Description

Reference: Shah, Dharmesh Mahendrabhai; Wader, Guruprasad Ramchandra; Mehta, Tushar Bharatkumar; Chavda, Rajendra Gokalbhai; Kathrotiya, Harshad Ghanshyambhai; Patel, Arpit Kiritbhai. Improved process for the preparation of lenvatinib. WO 2019016664. (Assignee BDR Lifesciences Private Limited, India)

Synthetic Reference

Shah, Dharmesh Mahendrabhai; Wader, Guruprasad Ramchandra; Mehta, Tushar Bharatkumar; Chavda, Rajendra Gokalbhai; Kathrotiya, Harshad Ghanshyambhai; Patel, Arpit Kiritbhai. Improved process for the preparation of lenvatinib. WO 2019016664. (Assignee BDR Lifesciences Private Limited, India)

Lenvatinib - Synthetic Route 4

Lenvatinib - Synthetic Route 4

Synthetic Description

Reference: Funahashi, Yasuhiro; Tsuruoka, Akihiko; Matsukura, Masayuki; Haneda, Toru; Fukuda, Yoshio; Kamata, Junichi; Takahashi, Keiko; Matsushima, Tomohiro; Miyazaki, Kazuki; Nomoto, Ken-Ichi; Watanabe, Tatsuo; Obaishi, Hiroshi; Yamaguchi, Atsumi; Suzuki, Sachi; Nakamura, Katsuji; Mimura, Fusayo; Yamamoto, Yuji; Matsui, Junji; Matsui, Kenji; Yoshiba, Takako; Suzuki, Yasuyuki; Arimoto, Itaru. Preparation of urea derivatives containing nitrogenous aromatic ring compounds as inhibitors of angiogenesis. US 7253286. (Assignee Eisai Co., Ltd, Japan)

Synthetic Reference

Funahashi, Yasuhiro; Tsuruoka, Akihiko; Matsukura, Masayuki; Haneda, Toru; Fukuda, Yoshio; Kamata, Junichi; Takahashi, Keiko; Matsushima, Tomohiro; Miyazaki, Kazuki; Nomoto, Ken-Ichi; Watanabe, Tatsuo; Obaishi, Hiroshi; Yamaguchi, Atsumi; Suzuki, Sachi; Nakamura, Katsuji; Mimura, Fusayo; Yamamoto, Yuji; Matsui, Junji; Matsui, Kenji; Yoshiba, Takako; Suzuki, Yasuyuki; Arimoto, Itaru. Preparation of urea derivatives containing nitrogenous aromatic ring compounds as inhibitors of angiogenesis. US 7253286. (Assignee Eisai Co., Ltd, Japan)

Lenvatinib - Synthetic Route 5

Lenvatinib - Synthetic Route 5

Synthetic Description

Reference: He, Peng; Wang, Xuechao; Deng, Ta; He, Qian. Method for preparing lenvatinib intermediate. CN 108997214. (Assignee Chengdu Diao Pharmaceutical Group Co., Ltd., Peop. Rep. China)

Synthetic Reference

He, Peng; Wang, Xuechao; Deng, Ta; He, Qian. Method for preparing lenvatinib intermediate. CN 108997214. (Assignee Chengdu Diao Pharmaceutical Group Co., Ltd., Peop. Rep. China)

Lenvatinib - Synthetic Route 6

Lenvatinib - Synthetic Route 6

Synthetic Description

Reference: Zheng, Shiyang; Zhi, Yonggang. Method for preparation of lenvatinib. CN 108658859. (Assignee Chengdu Organic Chemicals Co., Ltd., Chinese Academy of Sciences, Peop. Rep. China)

Synthetic Reference

Zheng, Shiyang; Zhi, Yonggang. Method for preparation of lenvatinib. CN 108658859. (Assignee Chengdu Organic Chemicals Co., Ltd., Chinese Academy of Sciences, Peop. Rep. China)

Lenvatinib - Synthetic Route 7

Lenvatinib - Synthetic Route 7

Synthetic Description

Reference: Ge, Wenlei; Gao, Junlong; Liu, Kai; Guo, Dapeng. Process for preparation of lenvatinib impurity 4,4'-(((carbonylbis(azanediyl))bis(3-chloro-4,1-phenylene))bis(oxy))bis(7-methoxyquinoline-6-carboxamide) or its salt. CN 108299294. (Assignee Jiangsu Hengrui Medicine Co., Ltd., Peop. Rep. China)

Synthetic Reference

Ge, Wenlei; Gao, Junlong; Liu, Kai; Guo, Dapeng. Process for preparation of lenvatinib impurity 4,4'-(((carbonylbis(azanediyl))bis(3-chloro-4,1-phenylene))bis(oxy))bis(7-methoxyquinoline-6-carboxamide) or its salt. CN 108299294. (Assignee Jiangsu Hengrui Medicine Co., Ltd., Peop. Rep. China)

Lenvatinib - Synthetic Route 8

Lenvatinib - Synthetic Route 8

Synthetic Description

Reference: Dong, Lichun; Hu, Geng; Li, Qi; Liu, Dianqing; Wang, Haoyuan. Synthesis method of anticancer drug lenvatinib. CN 107629001. (Assignee Chongqing University, Peop. Rep. China)

Synthetic Reference

Dong, Lichun; Hu, Geng; Li, Qi; Liu, Dianqing; Wang, Haoyuan. Synthesis method of anticancer drug lenvatinib. CN 107629001. (Assignee Chongqing University, Peop. Rep. China)

Lenvatinib - Synthetic Route 9

Lenvatinib - Synthetic Route 9

Synthetic Description

Reference: Jia, Huijuan; Chen, Yan; Zhang, Fan; He, Xuemin. Synthesis method of lenvatinib mesylate impurities. CN 107266363. (Assignee Hangzhou Huadong Medicine Group New Drug Research Institute Co., Ltd., Peop. Rep. China; Hangzhou Zhuyangxin Pharmaceutical Co., Ltd.; Zhejiang Huayi Pharmaceutical Co., Ltd.)

Synthetic Reference

Jia, Huijuan; Chen, Yan; Zhang, Fan; He, Xuemin. Synthesis method of lenvatinib mesylate impurities. CN 107266363. (Assignee Hangzhou Huadong Medicine Group New Drug Research Institute Co., Ltd., Peop. Rep. China; Hangzhou Zhuyangxin Pharmaceutical Co., Ltd.; Zhejiang Huayi Pharmaceutical Co., Ltd.)

Lenvatinib - Synthetic Route 10

Lenvatinib - Synthetic Route 10

Synthetic Description

Reference: Nakamura, Taiju; Abe, Taichi; Miyashita, Yusuke; Kuroda, Hirofumi; Ayata, Yusuke; Akao, Atsushi. Highly pure quinoline derivative and method for the preparation thereof. WO 2016031841. (Assignee Eisai R&D Management Co., Ltd., Japan)

Synthetic Reference

Nakamura, Taiju; Abe, Taichi; Miyashita, Yusuke; Kuroda, Hirofumi; Ayata, Yusuke; Akao, Atsushi. Highly pure quinoline derivative and method for the preparation thereof. WO 2016031841. (Assignee Eisai R&D Management Co., Ltd., Japan)