Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.
Saxty, Gordon; Murray, Christopher William; Berdini, Valerio; Besong, Gilbert Ebai; Hamlett, Christopher Charles Frederick; Johnson, Christopher Norbert; Woodhead, Steven John; Reader, Michael; Rees, David Charles; Mevellec, Laurence Anne; Angibaud, Patrick Rene; Freyne, Eddy Jean Edgard; Govaerts, Tom Cornelis Hortense; Weerts, Johan Erwin Edmond; Perera, Timothy Pietro Suren; Gilissen, Ronaldus Arnodus Hendrika Joseph; Wroblowski, Berthold; Lacrampe, Jean Fernand Armand; Papanikos, Alexandra; Querolle, Oliver Alexis Georges; Pasquier, Elisabeth Therese Jeanne; Pilatte, Isabelle Noeelle Constance; Bonnet, Pascal Ghislain Andre; Embrechts, Werner Constant Johan; Akkari, Rhalid; Meerpoel, Lieven Assignee Astex Therapeutics Limited,Nov 3, 2011 WO 2011135376 A1 UK 2011
Saxty, Gordon; Murray, Christopher William; Berdini, Valerio; Besong, Gilbert Ebai; Hamlett, Christopher Charles Frederick; Johnson, Christopher Norbert; Woodhead, Steven John; Reader, Michael; Rees, David Charles; Mevellec, Laurence Anne; Angibaud, Patrick Rene; Freyne, Eddy Jean Edgard; Govaerts, Tom Cornelis Hortense; Weerts, Johan Erwin Edmond; Perera, Timothy Pietro Suren; Gilissen, Ronaldus Arnodus Hendrika Joseph; Wroblowski, Berthold; Lacrampe, Jean Fernand Armand; Papanikos, Alexandra; Querolle, Oliver Alexis Georges; Pasquier, Elisabeth Therese Jeanne; Pilatte, Isabelle Noeelle Constance; Bonnet, Pascal Ghislain Andre; Embrechts, Werner Constant Johan; Akkari, Rhalid; Meerpoel, Lieven Assignee Astex Therapeutics Limited,Preparation of pyrazolylquinazoline derivatives for use as kinase inhibitor Nov 3, 2011 WO 2011135376 A1 UK 2011
