MedKoo Cat#: 584747 | Name: Mifentidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mifentidine is an H2-receptor antagonist.

Chemical Structure

Mifentidine
Mifentidine
CAS#83184-43-4

Theoretical Analysis

MedKoo Cat#: 584747

Name: Mifentidine

CAS#: 83184-43-4

Chemical Formula: C13H16N4

Exact Mass: 228.1375

Molecular Weight: 228.30

Elemental Analysis: C, 68.39; H, 7.06; N, 24.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Mifentidine
IUPAC/Chemical Name
N-(p-Imidazol-4-ylphenyl)-N'-isopropylformamidine
InChi Key
GOZUADYOHPCXLE-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
SMILES Code
CC(/N=C/NC1=CC=C(C2=CNC=N2)C=C1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Donetti A, Trummlitz G, Bietti G, Cereda E, Bazzano C, Wagner HU. Conformational studies of two histamine H2-receptor antagonistic phenylformamidines: mifentidine and its guanidinothiazole analogue DA 4643. Arzneimittelforschung. 1985;35(1A):306-15. PubMed PMID: 2859031. 2: Francalanza G, Franco C, Giachetti A. Mifentidine: evaluation of antiandrogen effects and kidney function studies. Arzneimittelforschung. 1985;35(1A):456-8. PubMed PMID: 2859037. 3: Scarpignato C, Tangwa M, Tramacere R, Del Soldato P. The effect of the new H2-receptor antagonist mifentidine on gastric secretion, gastric emptying and experimental gastric and duodenal ulcers in the rat: comparison with cimetidine and ranitidine. Digestion. 1986;33(1):7-16. PubMed PMID: 2866139. 4: Bertaccini G, Poli E, Coruzzi G. Action of the new H2-antagonist, DA 4577, on different in vitro and in vivo preparations. Agents Actions. 1984 Apr;14(3-4):510-5. PubMed PMID: 6145337. 5: Pattichis K, Kajbaf M, Gorrod JW. In vitro studies on the metabolic fate of mifentidine, a novel histamine H2-receptor antagonist. Eur J Drug Metab Pharmacokinet. 1997 Apr-Jun;22(2):155-64. PubMed PMID: 9248785. 6: Imbimbo BP, Urso R, Thieme G, Sturn B, Ueckert B, Vidi A, Ladinsky H, Daniotti S. Pharmacokinetics of mifentidine after single and multiple oral administration to healthy volunteers. Br J Clin Pharmacol. 1988 Oct;26(4):407-13. PubMed PMID: 2903762; PubMed Central PMCID: PMC1386562. 7: Bianchi Porro G, Imbimbo BP, Lazzaroni M. Effect of mifentidine on peptone meal-stimulated gastric acid secretion and plasma gastrin levels in duodenal ulcer patients. Agents Actions. 1988 Aug;25(1-2):22-6. PubMed PMID: 3055874. 8: Lazzaroni M, Imbimbo BP, Sangaletti O, Bianchi Porro G. Gastric acid and pepsin secretion after single oral doses of mifentidine in healthy subjects. Scand J Gastroenterol. 1988 Sep;23(7):788-92. PubMed PMID: 2906453. 9: Lazzaroni M, Ardizzone S, Imbimbo BP, Sangaletti O, Ghirardosi C, Bianchi Porro G. Effect of mifentidine, a new H2-antagonist, on pentagastrin-stimulated acid secretion in healthy subjects. Int J Clin Pharmacol Ther Toxicol. 1987 Apr;25(4):218-21. PubMed PMID: 2884190. 10: Kim DH, Kim EJ, Han SS, Roh JK, Jeong TC, Park JH. Inhibitory effects of H2-receptor antagonists on cytochrome P450 in male ICR mice. Hum Exp Toxicol. 1995 Aug;14(8):623-9. PubMed PMID: 7576828. 11: Reilly PE, Mason SR, Gillam EM. Differential inhibition of human liver phenacetin O-deethylation by histamine and four histamine H2-receptor antagonists. Xenobiotica. 1988 Apr;18(4):381-7. PubMed PMID: 2899931. 12: Pagani F, Micheletti R, Brambilla A, Schiavone A, Montagna E, Ciprandi C, Giachetti A. Pharmacology of mifentidine, a novel H2-receptor antagonist. Arzneimittelforschung. 1985;35(1A):451-5. PubMed PMID: 2859036. 13: Imbimbo BP, Seiberling M, Peuckert U, Hoexter G, Maier-Lenz H, Vidi A, Daniotti S. Safety and pharmacokinetics of mifentidine after increasing oral doses in healthy subjects. Eur J Clin Pharmacol. 1988;35(6):673-6. PubMed PMID: 2906876. 14: Brambilla A, Ghiorzi A, De Paoli AM, Giachetti A. Effect of mifentidine on mepirizole-induced duodenal ulcer in the rat. Pharmacol Res Commun. 1987 Dec;19(12):877-85. PubMed PMID: 2896364. 15: Donetti A, Cereda E, Ezhaya A, Micheletti R. N-(fluoroethyl)(imidazolylphenyl)formamidines. The issue of the active species of mifentidine. J Med Chem. 1989 May;32(5):957-61. PubMed PMID: 2565401. 16: Giachetti A, Pagani F, Micheletti R, Brambilla A, Cereda E, Donetti A. Pharmacological profile of mifentidine: a novel H2-receptor antagonist. Agents Actions. 1985 Apr;16(3-4):173-5. PubMed PMID: 2861730. 17: Bianchi Porro G, Lazzaroni M, Imbimbo BP, Sangaletti O, Ghirardosi C, Daniotti S. Action of mifentidine on the secretory response to sham feeding and pentagastrin and on serum gastrin in duodenal ulcer patients. Eur J Clin Pharmacol. 1987;32(6):555-8. PubMed PMID: 2888658. 18: Haaksma EE, Rademaker B, Kramer K, Eriks JC, Bast A, Timmerman H. Studies on the active molecular species of the H2 receptor antagonists cimetidine and mifentidine. J Med Chem. 1987 Jan;30(1):208-11. PubMed PMID: 3806596. 19: Erol DD, Rosen A. In vivo-in vitro correlations with a commercial dissolution simulator. Studies on the H2 receptor antagonist mifentidine. Arzneimittelforschung. 1996 Oct;46(10):986-9. PubMed PMID: 8931893. 20: Poli E, Coruzzi G, Bertaccini G. Action of mifentidine and ranitidine on the isolated rat uterus. Pharmacol Res Commun. 1984 Nov;16(11):1091-100. PubMed PMID: 6151674.